Effect of Varying Doses of a Monovalent H7N9 Influenza Vaccine With and Without AS03 and MF59 Adjuvants on Immune Response: A Randomized Clinical Trial.
Identifieur interne : 000B84 ( Main/Exploration ); précédent : 000B83; suivant : 000B85Effect of Varying Doses of a Monovalent H7N9 Influenza Vaccine With and Without AS03 and MF59 Adjuvants on Immune Response: A Randomized Clinical Trial.
Auteurs : Lisa A. Jackson [États-Unis] ; James D. Campbell [États-Unis] ; Sharon E. Frey [États-Unis] ; Kathryn M. Edwards [États-Unis] ; Wendy A. Keitel [États-Unis] ; Karen L. Kotloff [États-Unis] ; Andrea A. Berry [États-Unis] ; Irene Graham [États-Unis] ; Robert L. Atmar [États-Unis] ; C Buddy Creech [États-Unis] ; Isaac P. Thomsen [États-Unis] ; Shital M. Patel [États-Unis] ; Andres F. Gutierrez [États-Unis] ; Edwin L. Anderson [États-Unis] ; Hana M. El Sahly [États-Unis] ; Heather Hill [États-Unis] ; Diana L. Noah [États-Unis] ; Abbie R. Bellamy [États-Unis]Source :
- JAMA [ 1538-3598 ] ; 2015.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques (administration et posologie), Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Association médicamenteuse, Facteurs de l'âge, Femelle, Grippe humaine (), Grippe humaine (immunologie), Humains, Hémagglutination virale (immunologie), Mâle, Méthode en double aveugle, Polysorbates (administration et posologie), Sous-type H7N9 du virus de la grippe A, Squalène (administration et posologie), Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), alpha-Tocophérol (administration et posologie).
- MESH :
- administration et posologie : Adjuvants immunologiques, Polysorbates, Squalène, Vaccins antigrippaux, alpha-Tocophérol.
- effets indésirables : Vaccins antigrippaux.
- immunologie : Grippe humaine, Hémagglutination virale, Vaccins antigrippaux.
- sang : Anticorps antiviraux.
- Adulte, Adulte d'âge moyen, Association médicamenteuse, Facteurs de l'âge, Femelle, Grippe humaine, Humains, Mâle, Méthode en double aveugle, Sous-type H7N9 du virus de la grippe A, Tests d'inhibition de l'hémagglutination.
English descriptors
- KwdEn :
- Adjuvants, Immunologic (administration & dosage), Adult, Age Factors, Antibodies, Viral (blood), Double-Blind Method, Drug Combinations, Female, Hemagglutination Inhibition Tests, Hemagglutination, Viral (immunology), Humans, Influenza A Virus, H7N9 Subtype, Influenza Vaccines (administration & dosage), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control), Male, Middle Aged, Polysorbates (administration & dosage), Squalene (administration & dosage), alpha-Tocopherol (administration & dosage).
- MESH :
- chemical , administration & dosage : Adjuvants, Immunologic, Influenza Vaccines, Polysorbates, Squalene, alpha-Tocopherol.
- chemical , adverse effects : Influenza Vaccines.
- chemical , blood : Antibodies, Viral.
- immunology : Hemagglutination, Viral, Influenza Vaccines, Influenza, Human.
- prevention & control : Influenza, Human.
- Adult, Age Factors, Double-Blind Method, Drug Combinations, Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H7N9 Subtype, Male, Middle Aged.
Abstract
Human infections with the avian influenza A(H7N9) virus were first reported in China in 2013 and continue to occur. Hemagglutinin H7 administered alone is a poor immunogen necessitating evaluation of adjuvanted H7N9 vaccines.
DOI: 10.1001/jama.2015.7916
PubMed: 26197184
Affiliations:
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Jackson</name><affiliation wicri:level="2"><nlm:affiliation>Group Health Research Institute, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Group Health Research Institute, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Campbell, James D" sort="Campbell, James D" uniqKey="Campbell J" first="James D" last="Campbell">James D. Campbell</name><affiliation wicri:level="3"><nlm:affiliation>Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Frey, Sharon E" sort="Frey, Sharon E" uniqKey="Frey S" first="Sharon E" last="Frey">Sharon E. Frey</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases, Allergy, and Immunology, Saint Louis University School of Medicine, St Louis, Missouri.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Division of Infectious Diseases, Allergy, and Immunology, Saint Louis University School of Medicine, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M" last="Edwards">Kathryn M. Edwards</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Keitel, Wendy A" sort="Keitel, Wendy A" uniqKey="Keitel W" first="Wendy A" last="Keitel">Wendy A. Keitel</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Kotloff, Karen L" sort="Kotloff, Karen L" uniqKey="Kotloff K" first="Karen L" last="Kotloff">Karen L. Kotloff</name><affiliation wicri:level="3"><nlm:affiliation>Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Berry, Andrea A" sort="Berry, Andrea A" uniqKey="Berry A" first="Andrea A" last="Berry">Andrea A. Berry</name><affiliation wicri:level="3"><nlm:affiliation>Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>Division of Infectious Disease and Tropical Pediatrics, Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine</wicri:orgArea></affiliation></author><author><name sortKey="Graham, Irene" sort="Graham, Irene" uniqKey="Graham I" first="Irene" last="Graham">Irene Graham</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases, Allergy, and Immunology, Saint Louis University School of Medicine, St Louis, Missouri.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Division of Infectious Diseases, Allergy, and Immunology, Saint Louis University School of Medicine, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="Atmar, Robert L" sort="Atmar, Robert L" uniqKey="Atmar R" first="Robert L" last="Atmar">Robert L. Atmar</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Creech, C Buddy" sort="Creech, C Buddy" uniqKey="Creech C" first="C Buddy" last="Creech">C Buddy Creech</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Thomsen, Isaac P" sort="Thomsen, Isaac P" uniqKey="Thomsen I" first="Isaac P" last="Thomsen">Isaac P. Thomsen</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt Vaccine Research Program, Vanderbilt University Medical Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Patel, Shital M" sort="Patel, Shital M" uniqKey="Patel S" first="Shital M" last="Patel">Shital M. Patel</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Gutierrez, Andres F" sort="Gutierrez, Andres F" uniqKey="Gutierrez A" first="Andres F" last="Gutierrez">Andres F. Gutierrez</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Anderson, Edwin L" sort="Anderson, Edwin L" uniqKey="Anderson E" first="Edwin L" last="Anderson">Edwin L. Anderson</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases, Allergy, and Immunology, Saint Louis University School of Medicine, St Louis, Missouri.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Division of Infectious Diseases, Allergy, and Immunology, Saint Louis University School of Medicine, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="El Sahly, Hana M" sort="El Sahly, Hana M" uniqKey="El Sahly H" first="Hana M" last="El Sahly">Hana M. El Sahly</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Hill, Heather" sort="Hill, Heather" uniqKey="Hill H" first="Heather" last="Hill">Heather Hill</name><affiliation wicri:level="2"><nlm:affiliation>The EMMES Corporation, Rockville, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>The EMMES Corporation, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Noah, Diana L" sort="Noah, Diana L" uniqKey="Noah D" first="Diana L" last="Noah">Diana L. Noah</name><affiliation wicri:level="2"><nlm:affiliation>Southern Research Institute, Birmingham, Alabama.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Southern Research Institute, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Bellamy, Abbie R" sort="Bellamy, Abbie R" uniqKey="Bellamy A" first="Abbie R" last="Bellamy">Abbie R. Bellamy</name><affiliation wicri:level="2"><nlm:affiliation>The EMMES Corporation, Rockville, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>The EMMES Corporation, Rockville</wicri:cityArea></affiliation></author></analytic><series><title level="j">JAMA</title><idno type="eISSN">1538-3598</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adjuvants, Immunologic (administration & dosage)</term><term>Adult</term><term>Age Factors</term><term>Antibodies, Viral (blood)</term><term>Double-Blind Method</term><term>Drug Combinations</term><term>Female</term><term>Hemagglutination Inhibition Tests</term><term>Hemagglutination, Viral (immunology)</term><term>Humans</term><term>Influenza A Virus, H7N9 Subtype</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Male</term><term>Middle Aged</term><term>Polysorbates (administration & dosage)</term><term>Squalene (administration & dosage)</term><term>alpha-Tocopherol (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adjuvants immunologiques (administration et posologie)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Association médicamenteuse</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Hémagglutination virale (immunologie)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Polysorbates (administration et posologie)</term><term>Sous-type H7N9 du virus de la grippe A</term><term>Squalène (administration et posologie)</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins antigrippaux (immunologie)</term><term>alpha-Tocophérol (administration et posologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adjuvants, Immunologic</term><term>Influenza Vaccines</term><term>Polysorbates</term><term>Squalene</term><term>alpha-Tocopherol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Polysorbates</term><term>Squalène</term><term>Vaccins antigrippaux</term><term>alpha-Tocophérol</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Hémagglutination virale</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Hemagglutination, Viral</term><term>Influenza Vaccines</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Double-Blind Method</term><term>Drug Combinations</term><term>Female</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A Virus, H7N9 Subtype</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association médicamenteuse</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Sous-type H7N9 du virus de la grippe A</term><term>Tests d'inhibition de l'hémagglutination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human infections with the avian influenza A(H7N9) virus were first reported in China in 2013 and continue to occur. Hemagglutinin H7 administered alone is a poor immunogen necessitating evaluation of adjuvanted H7N9 vaccines.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li><li>Maryland</li><li>Missouri (État)</li><li>Tennessee</li><li>Texas</li><li>Washington (État)</li></region><settlement><li>Baltimore</li></settlement></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Jackson, Lisa A" sort="Jackson, Lisa A" uniqKey="Jackson L" first="Lisa A" last="Jackson">Lisa A. Jackson</name></region><name sortKey="Anderson, Edwin L" sort="Anderson, Edwin L" uniqKey="Anderson E" first="Edwin L" last="Anderson">Edwin L. Anderson</name><name sortKey="Atmar, Robert L" sort="Atmar, Robert L" uniqKey="Atmar R" first="Robert L" last="Atmar">Robert L. Atmar</name><name sortKey="Bellamy, Abbie R" sort="Bellamy, Abbie R" uniqKey="Bellamy A" first="Abbie R" last="Bellamy">Abbie R. Bellamy</name><name sortKey="Berry, Andrea A" sort="Berry, Andrea A" uniqKey="Berry A" first="Andrea A" last="Berry">Andrea A. Berry</name><name sortKey="Campbell, James D" sort="Campbell, James D" uniqKey="Campbell J" first="James D" last="Campbell">James D. Campbell</name><name sortKey="Creech, C Buddy" sort="Creech, C Buddy" uniqKey="Creech C" first="C Buddy" last="Creech">C Buddy Creech</name><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M" last="Edwards">Kathryn M. Edwards</name><name sortKey="El Sahly, Hana M" sort="El Sahly, Hana M" uniqKey="El Sahly H" first="Hana M" last="El Sahly">Hana M. El Sahly</name><name sortKey="Frey, Sharon E" sort="Frey, Sharon E" uniqKey="Frey S" first="Sharon E" last="Frey">Sharon E. Frey</name><name sortKey="Graham, Irene" sort="Graham, Irene" uniqKey="Graham I" first="Irene" last="Graham">Irene Graham</name><name sortKey="Gutierrez, Andres F" sort="Gutierrez, Andres F" uniqKey="Gutierrez A" first="Andres F" last="Gutierrez">Andres F. Gutierrez</name><name sortKey="Hill, Heather" sort="Hill, Heather" uniqKey="Hill H" first="Heather" last="Hill">Heather Hill</name><name sortKey="Keitel, Wendy A" sort="Keitel, Wendy A" uniqKey="Keitel W" first="Wendy A" last="Keitel">Wendy A. Keitel</name><name sortKey="Kotloff, Karen L" sort="Kotloff, Karen L" uniqKey="Kotloff K" first="Karen L" last="Kotloff">Karen L. Kotloff</name><name sortKey="Noah, Diana L" sort="Noah, Diana L" uniqKey="Noah D" first="Diana L" last="Noah">Diana L. Noah</name><name sortKey="Patel, Shital M" sort="Patel, Shital M" uniqKey="Patel S" first="Shital M" last="Patel">Shital M. Patel</name><name sortKey="Thomsen, Isaac P" sort="Thomsen, Isaac P" uniqKey="Thomsen I" first="Isaac P" last="Thomsen">Isaac P. Thomsen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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